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Tox

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Décadence et grandeur d\'un toxicomane repentant. \" L\'addiction est une maladie spirituelle. \" Telle est la conclusion qu\'a tirée le comédien Marc R ...

  • L'auteur : Marc RIOUFOL
  • Editeur: Robert Laffont
  • ISBN: 2221126181
  • Genre: Performing Arts
  • Nombre de pages: 285
  • Langue: French/English
  • Vues: 1593
  • Telecharger: 1593
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Détails: Décadence et grandeur d'un toxicomane repentant. " L'addiction est une maladie spirituelle. " Telle est la conclusion qu'a tirée le comédien Marc Rioufol de ses dix-neuf années de voyage dans la toxicomanie. Presque deux fois l'odyssée d'Ulysse, note-il. Enfant hypersensible né au sein d'une famille dysfonctionnelle de la bourgeoisie de province, le jeune Marc fait une rencontre décisive en la personne de Jacques de Bascher, ami avec Karl Lagerfeld. À ses côtés, il sera bientôt introduit parmi la fine fleur du gotha parisien, entre Le Sept et Les Bains Douches, où défile tout l'underground des années 1980, en même temps que les substances les plus convoitées. Blanche ou rose, la cocaïne est toujours pure ; ses effets décomplexent l'adolescent, entré comme par effraction dans les milieux de la mode ou de la nuit. Puis c'est l'escalade : déjà alcoolique, il se laisse aller à la consommation d'héroïne et de crack. Devenu junkie, il entre dans la spirale infernale du manque ; chaque dose entretient l'obsession qu'il ne parvient jamais à tenir à distance. Dix-sept cures, sept psys et un coma plus tard, un centre de traitement pilote lui permet miraculeusement de décrocher. Marc a désormais trente-deux ans, pas de situation, pas de repère ni de goût particulier. Il s'agit de naître à nouveau. Mais le singe, ce démon de la tentation, est toujours là " à frapper à la fenêtre ". Comment l'éloigner durablement ? Comment construire sa vie loin de toute addiction quand même un médicament peut provoquer la rechute ? Marc Rioufol parle de son expérience au sein des fraternités anonymes, ces associations composées de dépendants en résilience qui, régulièrement, se réunissent pour rester abstinents. En marge de ce réseau d'entraide, il entreprend une quête spirituelle sur mesure entre bouddhisme, Kabbale, gnose et catholicisme. Il ira jusqu'au Pérou pour expérimenter des techniques chamaniques susceptibles de l'aider à se délivrer du mal... Plus qu'un livre sur l'addiction, Marc Rioufol nous offre un récit d'apprentissage où un jeune homme, qui s'est rêvé une vie de luxe et de volupté décadente, découvre sur le tard les vertus de la parole et de l'authenticité. Ce qui, avouons-le, n'est pas le parcours ordinaire d'un acteur de cinéma...


The Warrior's Seal (The Tox Files)

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A Special Forces team is thrust into a war with the past to save the president after an artifact unleashes a deadly toxin. Special Forces operative Cole "T ...

  • L'auteur : Ronie Kendig
  • Editeur: Baker Books
  • ISBN: 1441229485
  • Genre: Fiction
  • Nombre de pages: 128
  • Langue: French/English
  • Vues: 1574
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Détails: A Special Forces team is thrust into a war with the past to save the president after an artifact unleashes a deadly toxin. Special Forces operative Cole "Tox" Russell and his team are tasked in a search-and-rescue--the U.S. president has been kidnapped during a goodwill tour. The mission nosedives when an ancient biblical artifact and a deadly toxin wipe out villages. Tox must stop the terrorists and the toxin to save the president.


Crown of Souls (The Tox Files Book #2)

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"Kendig has out done herself."--RT Book Reviews on Conspiracy of Silence Six months after stopping a deadly plague, Cole "Tox" Russell and his team are enj ...

  • L'auteur : Ronie Kendig
  • Editeur: Bethany House
  • ISBN: 1493411942
  • Genre: Fiction
  • Nombre de pages: 480
  • Langue: French/English
  • Vues: 1672
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Détails: "Kendig has out done herself."--RT Book Reviews on Conspiracy of Silence Six months after stopping a deadly plague, Cole "Tox" Russell and his team are enjoying a little rest. That peace is short-lived when a sniper shot hits Tox. The enemy is discovered to be one of their own, a rogue Special Forces team operator. Alec King is perhaps the only person as skilled as Tox, and he's out for justice. Furious with orders that got his men killed, he intends to make those responsible pay. And he insists Tox join him, believing they are the same breed of soldier. Afraid his old friend is right, Tox battles a growing darkness within himself as he and his team engage in another deadly encounter with antiquity. It appears Alec is cheating--he's using a mysterious artifact, a crown that history has linked to some of the worst slaughters in humanity. Racing to stop Alec before his vengeance is unleashed, Tox must fight the monster without becoming one.


Thirst of Steel (The Tox Files Book #3)

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Dismantled centuries ago, the sword of Goliath is still rumored to thirst for its enemies' blood. Cole "Tox" Russell only wants to begin his life with Have ...

  • L'auteur : Ronie Kendig
  • Editeur: Baker Books
  • ISBN: 1493414755
  • Genre: Fiction
  • Nombre de pages: 464
  • Langue: French/English
  • Vues: 1280
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Détails: Dismantled centuries ago, the sword of Goliath is still rumored to thirst for its enemies' blood. Cole "Tox" Russell only wants to begin his life with Haven Cortes, but he must first complete a final mission: retrieve that sword and destroy the deadly Arrow & Flame Order. The AFO, however, is determined to claim the sword. Wielding their father's life over Tzivia and Ram Khalon, they threaten to expose Ram's long-held and dangerous secret while demanding Tzivia locate the sword. With the Wraith team slowly being torn apart, things only worsen when Mercy Maddox, a new operative, emerges with the stunning news that the sword is tied to both Ram's secret and a string of unsolved serial murders. Tox, Ram, and the others are forced to set aside fear and anger to focus only on the enemy. No matter the cost, Wraith must stop or take the enemy down with them.


TOX-SICK

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“It’s as if we are all on a big, chemical drunk, and the hangover is a killer.” —Suzanne Somers, in TOX-SICK Pioneering health and wellness advocat ...

  • L'auteur : Suzanne Somers
  • Editeur: Harmony
  • ISBN: 0385347731
  • Genre: Health & Fitness
  • Nombre de pages: 384
  • Langue: French/English
  • Vues: 1942
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Détails: “It’s as if we are all on a big, chemical drunk, and the hangover is a killer.” —Suzanne Somers, in TOX-SICK Pioneering health and wellness advocate, Suzanne Somers, delivers a powerful answer in this expose on the immediate and long-term dangers of living in a world that has become increasingly toxic to our health. The build-up of toxins in our bodies can lead to myriad health concerns — including weight gain, food allergies, brain disorders, cancer, among many others. Moved to investigate by her own family’s plight, Suzanne sits down with environmental doctors and specialists who share eye-opening information and practical advice for how to survive, thrive, and stay healthy today. In Tox-Sick you’ll learn how to effectively detox all your body’s systems and the different survival skills that can save your life, from top experts in the field, including: • Dr. Sherry Rogers, an environmental doctor for over 40 years, shares the truth about detoxification—and where you will likely be if you don’t take it seriously. • Dr. Nicholas Gonzales shares where cancer comes from and how to manage it by detoxifying the liver and supplementing with enzymes. • Dr. Ritchie Shoemaker alerts you to mold toxicity, the newest threat to your brain and wellbeing…and just what to do to fight for your health. • Dr. Walter Crinnion teaches what everyday objects to avoid and the simple diet and lifestyle shifts to clean up your health and home in mere weeks! • Dr. Stephen Sinatra, America’s leading integrative cardiologist, explains that we have been approaching heart disease all wrong: a healthy gut, detoxed body, and quality fats are each crucial and cardioprotective. • Dr. Gary Gordon shares new protocols for removing toxic lead from the body, as well as ways to keep the most important gland in your body, the thyroid, clean and healthy. From diet and supplement advice to coconut oil cleanses, everything you need to live clean and enjoy great health is in your hands.


Low Tox Life

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Ever stopped to read the list of ingredients in the products you use every day? In Low Tox Life, activist and educator Alexx Stuart gently clears a path th ...

  • L'auteur : Alexx Stuart
  • Editeur: Allen & Unwin
  • ISBN: 176063641X
  • Genre: Health & Fitness
  • Nombre de pages: 272
  • Langue: French/English
  • Vues: 841
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Détails: Ever stopped to read the list of ingredients in the products you use every day? In Low Tox Life, activist and educator Alexx Stuart gently clears a path through the maze of mass-market ingredient cocktails, focusing on four key areas: Body, Home, Food and Mind. Sharing the latest science and advice from experts in each area, Alexx tackles everything from endocrine-disruptors in beauty products to the challenge of going low plastic in a high-plastic world, and how to clean without a hit of harmful toxins. You don't need to be a fulltime homesteader with a cupboard full of organic linens to go low tox. Start small, switching or ditching one nasty at a time, and enjoy the process as a positive one for you and the planet.


Le ciel sur la tête

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À la prison d’Étry, jour du printemps, c’est la mutinerie chez les jeunes détenus de l’unité 221. Au début, il s’agit juste de demander deux h ...

  • L'auteur : Nan Aurousseau
  • Editeur: Stock
  • ISBN: 2234065399
  • Genre: Fiction
  • Nombre de pages: 208
  • Langue: French/English
  • Vues: 513
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Détails: À la prison d’Étry, jour du printemps, c’est la mutinerie chez les jeunes détenus de l’unité 221. Au début, il s’agit juste de demander deux heures de promenade, en refusant de réintégrer les cellules. Mais les événements dégénèrent. Et ça fait mal. Policiers à l’hosto, surveillants enragés. La mutinerie est matée par les groupes d’intervention, et les meneurs envoyés au quartier disciplinaire des adultes. Se retrouvent alors en cellule isolée : un jeune braqueur déterminé, mais non dépourvu d’idéalisme ; une graine de mafia capable de tuer avec un stylo ; un étudiant apeuré, qui n’a rien à faire là ; un dangereux illuminé, échappé du quartier de haute sécurité. Face à eux : un sous-directeur un peu dépassé, obnubilé par une vengeance personnelle, un surveillant-chef proche de la retraite et des éducateurs sans moyens. Là où règne la loi du plus fort, beaucoup tentent de sauver leur peau. Comme partout ailleurs. Le ciel sur la tête est un roman noir, qui nous plonge avec violence et crudité dans l’univers carcéral. À travers une description saisissante de la prison, il pointe les échecs du pouvoir politique, le manque de moyens des éducateurs, le problème des jeunes en prison. Âpre, sans concessions, c’est un livre profondément humain.


Tox

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Met Tox schreef Paul Mennes (1967) een meeslepende roman over de jeugd in een Vlaams provinciegat. Orf, het hoofdpersonage, is één brok onverschilligheid ...

  • L'auteur : Paul Mennes
  • Editeur: Singel Uitgeverijen
  • ISBN: 9038895569
  • Genre: Fiction
  • Nombre de pages: N.A
  • Langue: French/English
  • Vues: 1746
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Détails: Met Tox schreef Paul Mennes (1967) een meeslepende roman over de jeugd in een Vlaams provinciegat. Orf, het hoofdpersonage, is één brok onverschilligheid. Alleen zijn steeds extremere onderwerpingsfantasieën over de Blonde Motorgod tonen iets van gevoel. Tox, zijn beste vriend, zou alles doen om zijn neus met 'ego' te vullen. En Belladonna, een vriendin, is op zijn minst prettig gestoord. Het is de eerste keer in de Vlaamse literatuur dat de huidige lost generation zo bijtend beschreven wordt. En het prachtige taalgebruik van de jonge debutant Paul Mennes maakt van Tox een heel bijzonder boek.


Principles of Uncertainty

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Praise for the first edition: Principles of Uncertainty is a profound and mesmerising book on the foundations and principles of subjectivist or behaviouris ...

  • L'auteur : Joseph B. Kadane
  • Editeur: CRC Press
  • ISBN: 1351683365
  • Genre: Mathematics
  • Nombre de pages: 498
  • Langue: French/English
  • Vues: 777
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Détails: Praise for the first edition: Principles of Uncertainty is a profound and mesmerising book on the foundations and principles of subjectivist or behaviouristic Bayesian analysis. ... the book is a pleasure to read. And highly recommended for teaching as it can be used at many different levels. ... A must-read for sure! —Christian Robert, CHANCE It's a lovely book, one that I hope will be widely adopted as a course textbook. —Michael Jordan, University of California, Berkeley, USA Like the prize-winning first edition, Principles of Uncertainty, Second Edition is an accessible, comprehensive text on the theory of Bayesian Statistics written in an appealing, inviting style, and packed with interesting examples. It presents an introduction to the subjective Bayesian approach which has played a pivotal role in game theory, economics, and the recent boom in Markov Chain Monte Carlo methods. This new edition has been updated throughout and features new material on Nonparametric Bayesian Methods, the Dirichlet distribution, a simple proof of the central limit theorem, and new problems. Key Features: First edition won the 2011 DeGroot Prize Well-written introduction to theory of Bayesian statistics Each of the introductory chapters begins by introducing one new concept or assumption Uses "just-in-time mathematics"—the introduction to mathematical ideas just before they are applied


Fundamentals Of Aquatic Toxicology

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This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including ...

  • L'auteur : Gary M. Rand
  • Editeur: CRC Press
  • ISBN: 1000124576
  • Genre: Science
  • Nombre de pages: 1148
  • Langue: French/English
  • Vues: 1483
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Détails: This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards. The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies.


The Complete Works of Charles Dickens: Novels, Short Stories, Plays, Poetry, Essays, Articles, Speeches, Travel Sketches & Letters (Illustrated)

Telecharger pdf The Complete Works of Charles Dickens: Novels, Short Stories, Plays, Poetry, Essays, Articles, Speeches, Travel Sketches & Letters (Illustrated)

This carefully crafted ebook: “The Complete Works of Charles Dickens” is formatted for your eReader with a functional and detailed table of contents: N ...

  • L'auteur : Charles Dickens
  • Editeur: e-artnow
  • ISBN: 8026873122
  • Genre: Fiction
  • Nombre de pages: 19203
  • Langue: French/English
  • Vues: 885
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Détails: This carefully crafted ebook: “The Complete Works of Charles Dickens” is formatted for your eReader with a functional and detailed table of contents: Novels Oliver Twist The Pickwick Papers Nicholas Nickleby The Old Curiosity Shop Barnaby Rudge Martin Chuzzlewit Dombey and Son David Copperfield Bleak House Hard Times Little Dorrit A Tale of Two Cities Great Expectations Our Mutual Friend The Mystery of Edwin Drood Christmas Novellas A Christmas Carol The Chimes The Cricket on the Hearth The Battle of Life The Haunted Man Short Story Collections Sketches by Boz Sketches of Young Gentlemen Sketches of Young Couples Master Humphrey' Clock Reprinted Pieces The Mudfog Papers Pearl-Fishing (First Series) Pearl-Fishing (Second Series) Christmas Stories Other Stories Children's Books Child's Dream of a Star Holiday Romance Stories About Children Every Child Can Read Dickens's Children Plays The Village Coquettes The Strange Gentleman The Lamplighter Is She His Wife Mr. Nightingale's Diary No Thoroughfare The Frozen Deep Poetry The Loving Ballad of Lord Bateman The Poems and Verses of Charles Dickens Travel Books American Notes Pictures From Italy The Lazy Tour of Two Idle Apprentices Other Works Sunday Under Three Heads A Child's History of England Memoirs of Joseph Grimaldi The Life of Our Lord The Uncommercial Traveller Contributions to “All The Year Round” Contributions to “The Examiner” Miscellaneous Papers Essays & Articles A Coal Miner's Evidence The Lost Arctic Voyagers Frauds on the Fairies Adelaide Anne Procter In Memoriam W. M. Thackeray Speeches of Charles Dickens: Literary and Social Letters of Charles Dickens Criticism CHARLES DICKENS by G. K. Chesterton DICKENS by Sir Adolphus William Ward THE LIFE OF CHARLES DICKENS by John Forster MY FATHER AS I RECALL HIM by Mamie D. Charles Dickens (1812-1870), an English writer and social critic, created some of the world's best-known fictional characters and is regarded as the greatest novelist of the Victorian era.


Immunotoxins

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Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbook ...

  • L'auteur : Arthur E. Frankel
  • Editeur: Springer Science & Business Media
  • ISBN: 1461310830
  • Genre: Medical
  • Nombre de pages: 566
  • Langue: French/English
  • Vues: 994
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Détails: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Un fortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.


Dombey and Son

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Dealings with the Firm of Dombey and Son: Wholesale, Retail and for Exportation is one of the best novels by Charles Dickens. This novel astonishes by the ...

  • L'auteur : Charles Dickens
  • Editeur: Strelbytskyy Multimedia Publishing
  • ISBN:
  • Genre: Fiction
  • Nombre de pages: N.A
  • Langue: French/English
  • Vues: 571
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Détails: Dealings with the Firm of Dombey and Son: Wholesale, Retail and for Exportation is one of the best novels by Charles Dickens. This novel astonishes by the endless number of figures and life situations. There are not many novels in the world literature, apart from some later works by Dickens, that are so rich and diversified in colours as Dombey and Son. The small bourgeois characters as well as representatives of the London poor class are created by him with huge love. Mostly all of these people are strange, but their eccentric behaviour, that is so funny, makes the characters close and sweet.


What's Next

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The story takes place a thousand years into the future. There is no more war because we are all living under a single world government, and we all vote on ...

  • L'auteur : Geoffrey Keane
  • Editeur: Author House
  • ISBN: 1477270396
  • Genre: Fiction
  • Nombre de pages: 364
  • Langue: French/English
  • Vues: 1612
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Détails: The story takes place a thousand years into the future. There is no more war because we are all living under a single world government, and we all vote on every issue of importance to us, educated by government emails and our internet access otherwise, but we have to pass a test showing that we understand the background and major considerations behind any issue we wish to vote on, otherwise we won't be able to vote on that issue. Politicians must do whatever the consensus vote subscribes, so we are truly represented as a people. However, there are still some issues where society has favored conservative protection, particularly of children, and despite social science observations that overly harsh consequences don't necessarily deter offenses of this nature, very harsh consequences are still prevalent, and they are more far reaching now because we have synthetic people (Androids) made of synthetic bone, muscle tissue and skin, and their computer brains are psychically linked to their owner, usually of the opposie sex; and of course our children can also become connected as well. This is a story of a family who's lives are changed by this new technology, yet they all mature and become educated over time, and some surprising things happen when you combine intelligence with technology!


Silicon Devices and Process Integration

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Silicon Devices and Process Integration covers state-of-the-art silicon devices, their characteristics, and their interactions with process parameters. It ...

  • L'auteur : Badih El-Kareh
  • Editeur: Springer Science & Business Media
  • ISBN: 0387690107
  • Genre: Technology & Engineering
  • Nombre de pages: 598
  • Langue: French/English
  • Vues: 1808
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Détails: Silicon Devices and Process Integration covers state-of-the-art silicon devices, their characteristics, and their interactions with process parameters. It serves as a comprehensive guide which addresses both the theoretical and practical aspects of modern silicon devices and the relationship between their electrical properties and processing conditions. The book is compiled from the author’s industrial and academic lecture notes and reflects years of experience in the development of silicon devices. Features include: A review of silicon properties which provides a foundation for understanding the device properties discussion, including mobility-enhancement by straining silicon; State-of-the-art technologies on high-K gate dielectrics, low-K dielectrics, Cu interconnects, and SiGe BiCMOS; CMOS-only applications, such as subthreshold current and parasitic latch-up; Advanced Enabling processes and process integration. This book is written for engineers and scientists in semiconductor research, development and manufacturing. The problems at the end of each chapter and the numerous charts, figures and tables also make it appropriate for use as a text in graduate and advanced undergraduate courses in electrical engineering and materials science.


Issues in Environmental Economics, Engineering, and Technology: 2011 Edition

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Issues in Environmental Economics, Engineering, and Technology: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and compr ...

  • L'auteur : N.A
  • Editeur: ScholarlyEditions
  • ISBN: 146496551X
  • Genre: Technology & Engineering
  • Nombre de pages: 821
  • Langue: French/English
  • Vues: 571
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Détails: Issues in Environmental Economics, Engineering, and Technology: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Environmental Economics, Engineering, and Technology. The editors have built Issues in Environmental Economics, Engineering, and Technology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Environmental Economics, Engineering, and Technology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Environmental Economics, Engineering, and Technology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.


Complete Novels

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This book, newly updated, contains now several HTML tables of contents that will make reading a real pleasure! The first table of contents (at the very beg ...

  • L'auteur : Charles Dickens
  • Editeur: AB Books
  • ISBN: 2291001043
  • Genre: Fiction
  • Nombre de pages: 20
  • Langue: French/English
  • Vues: 395
  • Telecharger: 395
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Détails: This book, newly updated, contains now several HTML tables of contents that will make reading a real pleasure! The first table of contents (at the very beginning of the ebook) lists the titles of all novels included in this volume. By clicking on one of those titles you will be redirected to the beginning of that work, where you'll find a new TOC that lists all the chapters and sub-chapters of that specific work. This book contains the complete novels of Charles Dickens in the chronological order of their original publication. - The Pickwick Papers - Oliver Twist - Nicholas Nickleby - The Old Curiosity Shop . - Barnaby Rudge - Martin Chuzzlewit - Dombey and Son - David Copperfield - Bleak House - Hard Times - Little Dorrit - A Tale of Two Cities - Great Expectations - Our Mutual Friend - The Mystery of Edwin Drood


Drug-like Properties: Concepts, Structure Design and Methods

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Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these ...

  • L'auteur : Li Di,Edward H Kerns
  • Editeur: Elsevier
  • ISBN: 0080557619
  • Genre: Science
  • Nombre de pages: 552
  • Langue: French/English
  • Vues: 1898
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Détails: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. * Serves as an essential working handbook aimed at scientists and students in medicinal chemistry * Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies * Discusses improvements in pharmacokinetics from a practical chemist's standpoint


Into The Nano Era

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Even as we tentatively enter the nanotechnology era, we are now encountering the 50th anniversary of the invention of the IC. Will silicon continue to be t ...

  • L'auteur : Howard Huff
  • Editeur: Springer Science & Business Media
  • ISBN: 3540745599
  • Genre: Technology & Engineering
  • Nombre de pages: 348
  • Langue: French/English
  • Vues: 1942
  • Telecharger: 1942
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Détails: Even as we tentatively enter the nanotechnology era, we are now encountering the 50th anniversary of the invention of the IC. Will silicon continue to be the pre-eminent material and will Moore’s Law continue unabated, albeit in a broader economic venue, in the nanotechnology era? This monograph addresses these issues by a re-examination of the scientific and technological foundations of the micro-electronics era. It also features two visionary articles of Nobel laureates.


The Role of the Study Director in Nonclinical Studies

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A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations ...

  • L'auteur : William J. Brock,Barbara Mounho,Lijie Fu
  • Editeur: John Wiley & Sons
  • ISBN: 1118874080
  • Genre: Science
  • Nombre de pages: 560
  • Langue: French/English
  • Vues: 1068
  • Telecharger: 1068
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Détails: A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry